Used the Autofocus routine every thirty minutes which works well in SharpCap and watched the live stack build up this time remembering to shoot a flat before starting so overcame the bright centre in the image as the stack developed and that worked well.
Info of kit and setting below, think the image can be made better once I re-learn the options in APP
Imaging kit : APM-LZOS 130/780 + 0.75x MR reducer / flattener, ASI2600MC-Pro + Esatto 4" Focuser
Mount : M-UNO Synscan
Guide : Skywatcher ED72Pro+0.8x reducer Altair 290M guide camera
Software: SharpCap, GSS Mount control software, PHD2, Stellarium, AstroPixelProcessor, Affinity Photo 1.9
Image 240 x 60s at 100g -10C / 25 Darks / 100 Flats / 100 Bias
2022.11.13 M31 Andromeda-Tweaked 240 1min by Nick Davis, on FlickrThanks For Looking
Cheers
Nick