So I decided to re-do M81 all over again.
And this is the dramatic (in the good way) result, it's like I used a completely other set of data.
There is WAY more detail in it, the dust lanes more defined, the weaker outer parts of M81 also visible, Holmberg IX (the faint blob on the left) is also better visible with even some detail in it, and so on.
And the colors are also "better", I used https://www.nasa.gov/feature/goddard/2017/messier-81 as reference.
Below is the scaled down version, but here is the full resolution: https://i.ibb.co/cTdJYgC/M81v2.jpg.
And for a total comparison, this is the March version: https://i.ibb.co/869926X/M81.jpg
Added also a detail comparison, here it shows very well that the March processing (left) has way less detail than the recent processing (right).
Menno

Left: March processing, right current processing